01
Couple as the unit of care
The reproductive unit — not the individual patient — is the first-class subject. Counselling, consent, screening and outcomes all bind to the couple.
01
Reproductive Genomics Atlas
Origin is the first clinical platform to unify the entire reproductive journey — preconception counselling, IVF, embryo selection, pregnancy monitoring and the handoff to newborn screening — in a single longitudinal record. Where the market relies on fragmented point-solutions across fertility clinics and reference labs, Origin treats the couple as the unit of care and the embryo as a first-class entity with its own outcome chain. Every prediction ships with calibrated confidence bands. Every decision lands in a tamper-evident audit trail.
01
Ancestry-Equitable Carrier Screening
Reference panels built on five population datasets (gnomAD, H3Africa, GenomeAsia, ABraOM, 1000 Genomes) to remove the European-population bias that under-identifies carriers in African, East Asian, South Asian and Indigenous populations.
02
Embryo as First-Class Entity
Each embryo carries its own state machine from fertilisation through cryostorage, transfer, pregnancy and neonatal outcome, with cryptographic chain-of-custody signing at each transition.
03
Mosaic Intelligence with Calibrated Confidence
Meiotic-vs-mitotic origin classification with calibrated confidence bands, anchored to a purpose-built mosaic-outcome cohort.
04
Closed-Loop Pharmacogenomic Stim Assistant
Dose recommendations from FSHR, ESR2, AMH, CYP19A1 and MTHFR variants coupled with real-time monitoring (E₂, follicle counts, wearables).
05
Multi-Party Consent Ledger
Purpose-built engine for couples, donors, surrogates and gestational carriers, with revocation tracking and an automated 18-year identity-release scheduler.
OPERATING PRINCIPLES
How Origin is built differently
Six structural commitments that shape every decision Origin records — from the schema layer up to the clinician’s screen.
02
Embryo with its own outcome chain
Each embryo carries an immutable record from fertilisation to neonatal handoff. Decisions are auditable backwards from any outcome.
03
Confidence bands, not point estimates
Every prediction — carrier risk, aneuploidy, mosaic outcome, fetal fraction — ships with a calibrated confidence interval.
04
Ancestry-equitable from day one
Reference panels built on five population datasets so screening accuracy does not collapse for non-European ancestries.
05
Cryptographic chain-of-custody
Every state transition — fertilisation, cryostorage, biopsy, transfer — is cryptographically signed and tamper-evident.
06
Compliance-native, not retrofitted
ACMG · ASRM · HFEA · ANVISA · LGPD · GDPR · HIPAA · FHIR R4 · GA4GH enforced at the platform layer, not bolted on per feature.
280
Days from preconception to neonatal handoff
The span Origin records end-to-end
5
Reference datasets for ancestry-equitable screening
gnomAD · H3Africa · GenomeAsia · ABraOM · 1000 Genomes
9%
Patients with >50% genomic ancestry inconsistent with self-report
Source: Nature (2020)